Compound
What is Tirzepatide?
9 September 2026
Overview
Tirzepatide is a synthetic peptide that acts on two incretin receptors, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Combining both activities in one molecule made it a widely studied compound in metabolic research.
Mechanism of action
By activating GIP and GLP-1 receptors together, Tirzepatide enhances insulin secretion in a glucose-dependent way while reducing glucagon release and slowing gastric emptying. Each effect mirrors one of the native incretin hormones; the interest lies in having both at once.
Research applications
The main lines of investigation are:
- Glycaemic control – effects on blood glucose regulation
- Insulin sensitivity – improvements in peripheral insulin action
- Body composition – redistribution of adipose tissue
- Cardiovascular markers – effects on lipid profiles and blood pressure
Molecular profile
| Property | Detail |
|---|---|
| Sequence length | 39 amino acids |
| Receptor targets | GIP, GLP-1 |
| Half-life | ~5 days |
| Molecular class | Synthetic peptide |
References
- Frias JP, et al. "Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes." NEJM, 2021.
- Jastreboff AM, et al. "Tirzepatide once weekly for the treatment of obesity." NEJM, 2022.
Draft wording prepared 2026-09-09, awaiting approval by Aevryn Labs Pty Ltd.